Title: Translating and evaluating single-cell Boolean network interventions in the multiscale setting

Abstract: Intracellular networks process cellular-level information and control cell fate. They can be computationally modeled using Boolean networks, implicit-time causal models of discrete binary events. These networks can be embedded into cell-agents of an agent-based model to drive cellular behavior. To explore this integration, we identify a set of candidate interventions that induce apoptosis in a cell-survival network of a rare leukemia using exhaustive search simulation, stable motif control, and an individual-based mean field approach (IBMFA). Due to algorithm constraints, these interventions are well-suited for cell-level decisions but less so for multicellular agent-based contexts. To address these limitations, we treat the target control solutions as putative therapeutic targets and develop a pipeline to translate them to continuous-time multicellular, agent-based models. We set the discrete-to-continuous transitions between the Boolean network and multicellular model via thresholding and produce simple computational simulations designed to emulate aspects of experimental and translational biology. Our results reveal that interventions performing equivalently in Boolean network simulations diverge in multiscale settings in both population growth and spatial distribution. Further analysis links these differences to internal network dynamics and the intervention’s proximity to output nodes. This proof-of-concept study highlights the importance of accounting for internal dynamics in multicellular simulations and advances understanding of Boolean network control.

Title: Spatial Dynamics of Vector Borne Diseases

Abstract: Vector-borne diseases affects approximately 1 billion people and accounts for 17% of all infectious diseases. With travel becoming more frequent across the global, it is important to understand the spatial dynamics of vector-borne diseases. Host movement plays a key part on how a disease can be distributed as it enables a pathogen to invade a new environment, and helps the persistence of a disease in locations that would otherwise be isolated. In this talk, we will explore how spatial heterogeneity combines with mobility network structure to influence vector-borne disease dynamics

Title: Spatial Dynamics of Vector Borne Diseases

Abstract: Vector-borne diseases affects approximately 1 billion people and accounts for 17% of all infectious diseases. With travel becoming more frequent across the global, it is important to understand the spatial dynamics of vector-borne diseases. Host movement plays a key part on how a disease can be distributed as it enables a pathogen to invade a new environment, and helps the persistence of a disease in locations that would otherwise be isolated. In this talk, we will explore how spatial heterogeneity combines with mobility network structure to influence vector-borne disease dynamics

Title: Radiative transport and optical tomography

Abstract: Optical tomography is the process of reconstructing the optical parameters of the inside of an object from measurements taken on the boundary.  This problem is hard if light inside the object is scattered -- if it bounces around a lot and refuses to travel in straight lines. To solve optical tomography problems, we need a mathematical model for light propagation inside a scattering medium. In this talk I'll give a brief introduction to one such model -- the radiative transport model -- and talk a little bit about its behavior and its implications for optical tomography.

Title: Radiative transport and optical tomography

Abstract: Optical tomography is the process of reconstructing the optical parameters of the inside of an object from measurements taken on the boundary.  This problem is hard if light inside the object is scattered -- if it bounces around a lot and refuses to travel in straight lines. To solve optical tomography problems, we need a mathematical model for light propagation inside a scattering medium. In this talk I'll give a brief introduction to one such model -- the radiative transport model -- and talk a little bit about its behavior and its implications for optical tomography.

Title: Qualitative Assesment of the Role of Temperature Variations on Malaria Transmission Dynamics

Speaker: Folashade B. Agusto, Department of Ecology and Evolutionary Biology, University of Kansa

Abstract:

A new mechanistic deterministic model for assessing the impact of temperature variability on malaria transmission dynamics is developed. The effects of sensitivity and uncertainty in estimates of the parameter values used in numerical simulations of the model are analysed. These analyses reveal that, for temperatures in the range [16-34]°C, the parameters of the model that have the dominant influence on the disease dynamics are the mosquito carrying capacity, transmission probability per contact for susceptible mosquitoes, human recruit- ment rate, mosquito maturation rate, biting rate, transmission probability per contact for susceptible humans, and recovery rate from first-time infections. This study emphasize the combined use of mosquito-reduction strategy and personal protection against mosquito bite during the periods when the mean monthly temperatures are in the range [16.7, 25]°C. For higher daily mean temperatures in the range [26, 34]°C, mosquito-reduction strategy should be emphasized ahead of personal protection. Numerical simulations of the model reveal that mosquito maturation rate has a minimum sensitivity (to the associated reproduction threshold of the model) at T = 24°C and maximum at T = 30°C. The mosquito biting rate has maximum sensitivity at T = 26°C, while the minimum value for the transmission probability per bite for susceptible mosquitoes occurs at T = 24°C. Furthermore, disease burden increases for temperatures between 16°C and 25°C and decreases beyond 25°C. This finding, which supports a recent study by other authors, suggests the importance of the role of global warming on future malaria transmission trends.

Title: Qualitative Assesment of the Role of Temperature Variations on Malaria Transmission Dynamics

Speaker: Folashade B. Agusto, Department of Ecology and Evolutionary Biology, University of Kansa

Abstract:

A new mechanistic deterministic model for assessing the impact of temperature variability on malaria transmission dynamics is developed. The effects of sensitivity and uncertainty in estimates of the parameter values used in numerical simulations of the model are analysed. These analyses reveal that, for temperatures in the range [16-34]°C, the parameters of the model that have the dominant influence on the disease dynamics are the mosquito carrying capacity, transmission probability per contact for susceptible mosquitoes, human recruit- ment rate, mosquito maturation rate, biting rate, transmission probability per contact for susceptible humans, and recovery rate from first-time infections. This study emphasize the combined use of mosquito-reduction strategy and personal protection against mosquito bite during the periods when the mean monthly temperatures are in the range [16.7, 25]°C. For higher daily mean temperatures in the range [26, 34]°C, mosquito-reduction strategy should be emphasized ahead of personal protection. Numerical simulations of the model reveal that mosquito maturation rate has a minimum sensitivity (to the associated reproduction threshold of the model) at T = 24°C and maximum at T = 30°C. The mosquito biting rate has maximum sensitivity at T = 26°C, while the minimum value for the transmission probability per bite for susceptible mosquitoes occurs at T = 24°C. Furthermore, disease burden increases for temperatures between 16°C and 25°C and decreases beyond 25°C. This finding, which supports a recent study by other authors, suggests the importance of the role of global warming on future malaria transmission trends.

Title: Qualitative Assesment of the Role of Temperature Variations on Malaria Transmission Dynamics

Speaker: Folashade B. Agusto, Department of Ecology and Evolutionary Biology, University of Kansa

Abstract:

A new mechanistic deterministic model for assessing the impact of temperature variability on malaria transmission dynamics is developed. The effects of sensitivity and uncertainty in estimates of the parameter values used in numerical simulations of the model are analysed. These analyses reveal that, for temperatures in the range [16-34]°C, the parameters of the model that have the dominant influence on the disease dynamics are the mosquito carrying capacity, transmission probability per contact for susceptible mosquitoes, human recruit- ment rate, mosquito maturation rate, biting rate, transmission probability per contact for susceptible humans, and recovery rate from first-time infections. This study emphasize the combined use of mosquito-reduction strategy and personal protection against mosquito bite during the periods when the mean monthly temperatures are in the range [16.7, 25]°C. For higher daily mean temperatures in the range [26, 34]°C, mosquito-reduction strategy should be emphasized ahead of personal protection. Numerical simulations of the model reveal that mosquito maturation rate has a minimum sensitivity (to the associated reproduction threshold of the model) at T = 24°C and maximum at T = 30°C. The mosquito biting rate has maximum sensitivity at T = 26°C, while the minimum value for the transmission probability per bite for susceptible mosquitoes occurs at T = 24°C. Furthermore, disease burden increases for temperatures between 16°C and 25°C and decreases beyond 25°C. This finding, which supports a recent study by other authors, suggests the importance of the role of global warming on future malaria transmission trends.

Title: Qualitative Assesment of the Role of Temperature Variations on Malaria Transmission Dynamics

Speaker: Folashade B. Agusto, Department of Ecology and Evolutionary Biology, University of Kansa

Abstract:

A new mechanistic deterministic model for assessing the impact of temperature variability on malaria transmission dynamics is developed. The effects of sensitivity and uncertainty in estimates of the parameter values used in numerical simulations of the model are analysed. These analyses reveal that, for temperatures in the range [16-34]°C, the parameters of the model that have the dominant influence on the disease dynamics are the mosquito carrying capacity, transmission probability per contact for susceptible mosquitoes, human recruit- ment rate, mosquito maturation rate, biting rate, transmission probability per contact for susceptible humans, and recovery rate from first-time infections. This study emphasize the combined use of mosquito-reduction strategy and personal protection against mosquito bite during the periods when the mean monthly temperatures are in the range [16.7, 25]°C. For higher daily mean temperatures in the range [26, 34]°C, mosquito-reduction strategy should be emphasized ahead of personal protection. Numerical simulations of the model reveal that mosquito maturation rate has a minimum sensitivity (to the associated reproduction threshold of the model) at T = 24°C and maximum at T = 30°C. The mosquito biting rate has maximum sensitivity at T = 26°C, while the minimum value for the transmission probability per bite for susceptible mosquitoes occurs at T = 24°C. Furthermore, disease burden increases for temperatures between 16°C and 25°C and decreases beyond 25°C. This finding, which supports a recent study by other authors, suggests the importance of the role of global warming on future malaria transmission trends.

Title: Qualitative Assesment of the Role of Temperature Variations on Malaria Transmission Dynamics

Speaker: Folashade B. Agusto, Department of Ecology and Evolutionary Biology, University of Kansa

Abstract:

A new mechanistic deterministic model for assessing the impact of temperature variability on malaria transmission dynamics is developed. The effects of sensitivity and uncertainty in estimates of the parameter values used in numerical simulations of the model are analysed. These analyses reveal that, for temperatures in the range [16-34]°C, the parameters of the model that have the dominant influence on the disease dynamics are the mosquito carrying capacity, transmission probability per contact for susceptible mosquitoes, human recruit- ment rate, mosquito maturation rate, biting rate, transmission probability per contact for susceptible humans, and recovery rate from first-time infections. This study emphasize the combined use of mosquito-reduction strategy and personal protection against mosquito bite during the periods when the mean monthly temperatures are in the range [16.7, 25]°C. For higher daily mean temperatures in the range [26, 34]°C, mosquito-reduction strategy should be emphasized ahead of personal protection. Numerical simulations of the model reveal that mosquito maturation rate has a minimum sensitivity (to the associated reproduction threshold of the model) at T = 24°C and maximum at T = 30°C. The mosquito biting rate has maximum sensitivity at T = 26°C, while the minimum value for the transmission probability per bite for susceptible mosquitoes occurs at T = 24°C. Furthermore, disease burden increases for temperatures between 16°C and 25°C and decreases beyond 25°C. This finding, which supports a recent study by other authors, suggests the importance of the role of global warming on future malaria transmission trends.